Telomerase

Telomerase is an enzyme that enables cells to replicate indefinitely.
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GRN510 – A small molecule telomerase activator for senescence-related disease

Telomere loss may play a role in many degenerative diseases. Controlled activation of the enzyme telomerase may restore the regenerative and functional capacity of cells in various organ systems impacted by senescence, injury or chronic disease.

About GRN510

GRN510 is a novel and proprietary small molecule activator of telomerase based on compounds discovered through the screening of libraries of natural product extracts from traditional Chinese medicines.

Preclinical Data

Studies using cell-based and animal model systems have demonstrated the potential utility of small molecule telomerase activators in a range of human diseases associated with cellular senescence, fibrotic disorders and telomerase deficiency. Data were obtained in one study using a rodent model of Idiopathic Pulmonary Fibrosis (IPF), a chronic, progressive disease of the lung characterized by inflammation and fibrosis. Administration of GRN510 resulted in an increase in telomerase activity in lung tissue samples. In these preliminary studies, reductions in inflammatory cells in the lungs and improvements in lung compliance, or elasticity, were also observed.

Further studies are underway to determine the suitability of GRN510 as an investigational development candidate.

Related Publications

  • Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes. Journal of Immunology 181:7400-7406 (2008)
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Related Presentations

  • Telomerase activator prevents the development of lung fibrosis in a bleomycin mouse model. American Thoracic Society 2010 International Conference

Telomerase

Telomerase is an enzyme that enables cells to replicate indefinitely.
Learn more

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