Clinical Trials
Novel Approach
Imetelstat inhibits the activity of the enzyme telomerase, a key target for anti-cancer therapeutics.
Learn more
Imetelstat in Patients with Multiple Myeloma
Helpful Information
- Cytoreductive therapy is a treatment to reduce the size of a cancer tumor. This may also be referred to as "debulking." Surgery and chemotherapy are common cytoreductive therapies.
- A relapse is when cancer returns after a period of improvement.
- The response rate is the percentage of patients whose cancer decreases or disappears after treatment.
- Maintenance therapy is treatment given to help prevent cancer from coming back after it has decreased or disappeared following the initial therapy.
A Phase 2 Trial to Determine the Effect of Imetelstat (GRN163L) on Patients With Previously Treated Multiple Myeloma
Geron is enrolling patients in a clinical trial to determine the potential benefit of our product candidate, imetelstat, as a therapy for patients with multiple myeloma. This study is enrolling patients who have been previously treated with cytoreductive therapy and whose cancer has stabilized or partially responded, but who still have detectable, non-progressing cancer and who are considered most likely to relapse.
In this Phase 2 clinical trial, our clinical researchers and investigators are studying how imetelstat may affect the response rate of patients with previously treated multiple myeloma when given alone or in combination with lenalidomide maintenance therapy.
Additionally, we are collecting data on the change in myeloma cancer stem cells from the patient's bone marrow and circulation.
Imetelstat is an investigational treatment for cancer in development by Geron and has not been approved by the FDA or any other regulatory agency.
About Imetelstat
Imetelstat inhibits the activity of telomerase, which is an enzyme present in most types of cancer that enables tumor cells to replicate indefinitely. One of Geron's potential anti-cancer strategies is to stop or slow down the growth and spread of tumors by inhibiting telomerase activity. Learn more
Cancer Definitions
To learn more about the terms and definitions used in cancer clinical studies you may find the National Cancer Institute Dictionary of Cancer Terms a useful resource.
Para obtener más información acerca de los términos y las definiciones utilizadas en los estudios clínicos sobre el cáncer es posible que el Instituto Nacional del Cáncer Diccionario de cáncer en un recurso útil.
How to Participate
To learn more about how to participate in this clinical trial, please visit ClinicalTrials.gov for the full trial summary and enrollment criteria.
Additionally, patients or their physicians may directly contact the trial center for more information about how to participate. The study is currently being conducted in trial centers in the United States.
Novel Approach
Imetelstat inhibits the activity of the enzyme telomerase, a key target for anti-cancer therapeutics.
Learn more
