Selected Publications

For copies of selected scientific publications relevant to our cancer programs, email a request for literature at info@geron.com or call us at 650-473-7765.

Below is a list of the publications:

Document Title		Citation

Telomerase Inhibition

Telomere Dysfunction Alters the Chemotherapeutic Profile of Transformed Cells		PNAS, March 2001, Volume 98, No. 6

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability		Cell, October 2001, Volume 107

Allosteric Inhibitors of Telomerase: Oligonucleotide		Nucleic Acids Research, January 2002, Volume 30, No. 2

Perspectives - Telomerase Beyond Telomeres		Nature Reviews Cancer, August 2002, Volume 2

Interaction of Human Telomerase with Its Primer Substrate		Biochemistry, January 2003, Volume 42

hTERT Associates with Human Telomeres and Enhances Genomic Stability and DNA Repair		Oncogene, January 2003, Volume 22

Association Between Telomere Length and vh Gene Mutation Status in CLL: Clinical and Biological Implications		British Journal of Cancer, February 2003, Volume 88

A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent		Cancer Research, July 2003, Volume 63

Telomerase Inhibition with an Oligonucleotide Telomerase Template Antagonist		Blood, January 2004, Volume 102, Number 1

Anti-tumor Effects of Specific Telomerase Inhibitor GRN 163 in Human Glioblastoma Xenografts		Neuro-Oncology, July 2004, Volume 6, Issue 3

Lipid Modification of GRN163, an N3 P5 Thio-phosphoramidate Oligonucleotide, Enhances the Potency of Telomerase Inhibition		Oncogene, August 2005, Volume 24

In Vivo Inhibition of Lung Cancer by GRN163L: A Novel Human Telomerase Inhibitor		Cancer Research, September 2005, Volume 65

Telomerase Antagonists GRN163 and GRN163L Inhibit Tumor Growth and Increase Chemosensitivity of Human Hepatoma		Hepatology, November 2005, Volume 42

Effects of a Novel Telomerase Inhibitor, GRN163L, in Human Breast Cancer		Breast Cancer Research and Treatment, March 2006, Volume 96

Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth and Metastasis of Breast Cancer		Clinical Cancer Research, May 2006, Volume 12

Anti-adhesive Effects of GRN163L - An Oligonucleotide N3 P5 Thio-phosphoramidate Targeting Telomerase		Cancer Research, February 2007, Volume 67

Telomerase and Cancer Therapuetics		Nature Reviews Cancer, March 2008, Volume 8

Telomerase Vaccine

Telomerase mRNA-Transfected Dendritic Cells Stimulate Antigen-Specific CD8 and CD4 T Cell Responses in Patients with Metastatic Prostate Cancer		Journal of Immunology, March 2005, Volume 174

The Telomerase Catalytic Subunit is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes		Immunity, June 1999, Volume 10

Enhanced Induction of Telomerase-Specific CD4+ T Cells Using Dendritic Cells Transfected with RNA Encoding a Chimeric Gene Product		Cancer Research, September 1, 2002, Volume 62

Dendritic Cells Reconstituted with Human Telomerase Gene Induce Potent Cytotoxic T-Cell Response Against Different Types of Tumors		Cancer Gene Therapy, March 2003, Volume 10

Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes		Clinical Cancer Research, February 2004, Volume 10

Telomerase Pulsed Dendritic Cells for Immunotherapy for Renal Cell Carcinoma		Journal of Urology, January 2004, Volume 171

Cytotoxic T Cell Immunity Against Telomerase Reverse Transcriptase in Humans		PNAS, April 2000, Volume 97

Oncolytic Virus

Anti-tumor Efficacy and Tumor-Selective Replication with a Single Intravenous Injection of OAS403, an Oncolytic Adenovirus Dependent on Two Prevelant Alteration in Human Cancer		Cancer Gene Therapy, August 2004, Volume 11

Telomerase Diagnostics

A Survey of Telomerase Activity in Human Cancer		European Journal of Cancer, April 1997, Volume 33

Telomerase: Its Clinical Relevance in the Diagnosis of Bladder Cancer		Oncogene, January 2002, Volume 21