First Clinical Trial
In 2005, we initiated the first Phase 1 clinical trial of our first-in-class telomerase inhibitor, GRN163L, which later became known as imetelstat. Since telomerase is upregulated in most types of human cancers, we conducted a broad program of early phase clinical trials, including small single arm studies as well as larger multi-center randomized trials testing imetelstat as a single agent and as combination therapy with standard treatments both in solid tumors and hematologic malignancies. Over 500 patients have been enrolled and treated in Phase 1 and 2 clinical trials of imetelstat.
Data from these clinical trials led to the observation that imetelstat had potentially disease-modifying activity in hematologic myeloid malignancies, which has become our focus today.