September is Blood Cancer Awareness Month. We stand with everyone living with blood cancer — this month and every day.

Publications & Presentations

Advancing scientific understanding from research to real-world evidence.
Every study contributes to a deeper understanding of blood cancer and the potential for new treatment approaches. Through clinical trials, real-world evidence, investigator-sponsored research, and scientific collaboration, Geron is committed to generating evidence that may help advance science, inform clinical practice, and improve outcomes for people living with blood cancer.

Explore our scientific publications and presentations:

This page may contain non-exhaustive scientific information about post-hoc, exploratory, subgroup analyses, or uses that have not yet been approved by regulatory authorities. The information is provided for educational and scientific exchange purposes only, and does not suggest products should be used in a manner not consistent with their respective label approved by the regulatory authorities, which may differ by geography. Any publication reflects the state of knowledge at the time it was published. The information is not medical advice and cannot replace the independent medical judgement of a healthcare professional.

Journal articles

Increased duration of time without transfusion reliance with imetelstat vs placebo in the phase 3 IMerge trial

Blood Neoplasia

April 16, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Association between treatment-emergent cytopenias and clinical responses to imetelstat in lower-risk myelodysplastic syndromes

Blood Cancer Journal

April 7, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Imetelstat improves patient-reported outcomes and quality of life in lower-risk myelodysplastic syndromes: results from the phase III IMerge study

Haematologica Early View

January 22, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Modulation of the clonal burden in patients with lower-risk myelodysplastic neoplasms treated with imetelstat

Nature Leukemia

January 12, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS

Blood Cancer Journal

December 31, 2025
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower-Risk Myelodysplastic Syndromes

Clinical and Translational Science

December 14, 2025
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling

Frontiers in Oncology

October 1, 2023
Preclinical Data

Imetelstat in patients with lower-risk MDS who have relapsed or are refractory to erythropoiesis-stimulating agents in IMerge phase 3 trial

Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge):…

The Lancet

July 1, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia

Nature Cancer

July 1, 2023
Acute Myeloid Leukemia (AML)Preclinical Data

Telomerase-targeted therapies in myeloid malignancies

Blood Advances

July 1, 2023
Review

Pharmacological Inhibitory Effect of Imetelstat, A Novel Human Telomerase Inhibitor in Diffuse Large B-cell Lymphoma and Peripheral T-Cell Lymphoma

Blood

July 1, 2022
Preclinical Data

Imetelstat in intermediate-2 or high-risk myelofibrosis refractory to JAK inhibitor: IMpactMF phase III study design

Future Oncology

July 1, 2022
Myelofibrosis (MF)Clinical Data

Conference presentations

Imetelstat in RBC Transfusion-Dependent Lower Risk MDS Relapsed/Refractory to Erythropoiesis-Stimulating Agents (IMerge): Updated Efficacy and Safety

EHA 2018

June 12, 2018
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Efficacy and Safety of Imetelstat in RBC Transfusion-Dependent (TD) IPSS Low/Int-1 MDS Relapsed/Refractory to Erythropoiesis-Stimulating Agents (ESA) (IMerge)

ASH 2017

December 5, 2017
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Imetelstat, a Telomerase Inhibitor, Is Capable of Depleting Myelofibrosis Hematopoietic Stem Cells and Progenitor Cells

ASH 2017

December 5, 2017
Myelofibrosis (MF)Preclinical Data

Telomerase Inhibition Impairs Self-Renewal of b-Catenin Activated Myeloproliferative Neoplasm Progenitors

ASH 2017

December 5, 2017
Preclinical Data

Integrated Molecular Analysis Identifies Replicative Stress as Sensitizer to Imetelstat Therapy in AML

ASH 2017

December 5, 2017
Acute Myeloid Leukemia (AML)Preclinical Data

Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis in vitro and increases survival in vivo in acute myeloid leukemia

AACR 2017

April 15, 2017
Acute Myeloid Leukemia (AML)Preclinical Data

The preclinical efficacy of a novel telomerase inhibitor, imetelstat, in AML: A randomized trial in patient-derived xenografts

ASH 2016

December 5, 2016
Acute Myeloid Leukemia (AML)Preclinical Data

Telomerase Inhibition with Imetelstat Eradicates β-catenin Activated BC CML Stem Cells

ASH 2016

December 5, 2016
Preclinical Data

Characterization of Disease, Treatment Patterns, and Outcomes of Patients With Myelofibrosis: Analysis of Two United States Commercial Claims Databases

ASH 2016

December 5, 2016
Myelofibrosis (MF)

Myelosuppression in Patients Treated With the Telomerase Inhibitor Imetelstat is Not Mediated Through Activation of Toll-Like Receptors

AACR 2016

April 15, 2016
Clinical Data

Impact of Hypomethylating Agents on hTERT Expression and Synergistic Effect in Combination With Imetelstat, a Telomerase Inhibitor, in Acute Myeloid Leukemia Cell Lines

AACR 2016

April 15, 2016
Acute Myeloid Leukemia (AML)Preclinical Data

Telomerase Inhibitor Imetelstat Therapy in Refractory Anemia with Ring Sideroblasts with or without Thrombocytosis

ASH 2015

December 5, 2015
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data