September is Blood Cancer Awareness Month. We stand with everyone living with blood cancer — this month and every day.

Real-World Evidence

Learning from care in the real world
Clinical trials help us understand the safety and efficacy of medicines in carefully designed research settings. Real-world evidence helps broaden that understanding by providing insights into disease, treatments, and patient experiences in everyday clinical practice.

At Geron, real-world evidence (RWE) is an important part of our broader evidence-generation strategy—helping us continue to learn, ask new questions, and build on what we know from clinical research.

What is real-world evidence? 

RWE is clinical and/or economic evidence generated through the analysis of real-world data, which is information collected outside of traditional clinical trials. 

Real-world data can come from a variety of sources including electronic health records, insurance claims, patient registries, chart reviews, health surveys, and other sources that reflect routine clinical care and patient experiences.

When analyzed using appropriate scientific methods, these data can help researchers better understand how diseases are managed and how treatments are used in everyday practice.

Building a more complete picture

Clinical trials remain essential to evaluating new medicines. RWE can complement clinical trial data by helping answer additional questions about patients, treatment patterns, outcomes, and experiences in routine clinical practice.

At Geron, we are integrating RWE into our broader research and evidence-generation efforts to deepen our understanding of blood cancers and the patients affected by them.

Better understand patient populations, disease burden, and treatment journeys
Explore how treatments are used in routine clinical practice
Evaluate clinical and/or economic outcomes and patient experiences outside of clinical trials
Generate insights that may help inform future research and evidence-generation priorities
Continue building the body of evidence surrounding our medicines throughout their lifecycle

From clinical research to clinical practice

Our commitment to research does not end when a clinical trial is complete. We continue to generate and evaluate evidence to better understand how our medicines may impact patients across different settings over time. 

“By bringing together insights from clinical trials and real-world research, we aim to build a more complete understanding of the science, the treatment landscape, and the experiences of people living with blood cancer.”

— Brian Sweet

Health Economics & Outcomes Research (HEOR) · Geron

Advancing evidence through collaboration

Generating meaningful evidence takes collaboration. In addition to Geron-sponsored research, we support opportunities for independent investigators to explore important scientific questions, including research that may generate RWE.

If you are a qualified researcher or healthcare professional interested in conducting investigator-sponsored research related to Geron’s areas of scientific interest, learn more about our program and how to submit a proposal. 

Explore our real-world evidence

Our growing body of real-world research reflects our ongoing commitment to advancing scientific understanding and generating evidence that can help inform patient care. 

Real-world Outcomes of Imetelstat: Interrogating Safety, Efficacy and Predictors of Response in Heavily Pretreated Lower-Risk MDS Patients

EHA 2026

June 12, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Updated analysis of overall survival with imetelstat in relapsed/refractory myelofibrosis versus real-world data, and assessment of real-world treatment patterns

ASCO 2026

June 1, 2026
Myelofibrosis (MF)Clinical Data

Durable Transfusion Independence in Lower-Risk Myelodysplastic Syndrome (LR-MDS) Is Associated With Better Survival: A Population Level Analysis Based on a Large US Health Insurance Claims Database

ASH 2023

December 5, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Clinical and biological characterization of Low Risk MDS patients according to Ring Sideroblasts (RS). Comparison between the 3 subgroups in WHO2017 classification. Study from the Spanish MDS registry

ASH 2021

December 5, 2021
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Favorable overall survival with imetelstat in relapsed/refractory myelofibrosis patients compared with real-world data

Annals of Hematology

July 1, 2021
Myelofibrosis (MF)Clinical Data

Favorable Overall Survival of Imetelstat-treated Relapsed/Refractory Myelofibrosis Patients Compared with Closely Matched Real World Data

EHA 2019

June 12, 2019
Myelofibrosis (MF)Clinical Data

Characterization of Disease, Treatment Patterns, and Outcomes of Patients With Myelofibrosis: Analysis of Two United States Commercial Claims Databases

ASH 2016

December 5, 2016
Myelofibrosis (MF)