September is Blood Cancer Awareness Month. We stand with everyone living with blood cancer — this month and every day.

Publications & Presentations

Advancing scientific understanding from research to real-world evidence.
Every study contributes to a deeper understanding of blood cancer and the potential for new treatment approaches. Through clinical trials, real-world evidence, investigator-sponsored research, and scientific collaboration, Geron is committed to generating evidence that may help advance science, inform clinical practice, and improve outcomes for people living with blood cancer.

Explore our scientific publications and presentations:

This page may contain non-exhaustive scientific information about post-hoc, exploratory, subgroup analyses, or uses that have not yet been approved by regulatory authorities. The information is provided for educational and scientific exchange purposes only, and does not suggest products should be used in a manner not consistent with their respective label approved by the regulatory authorities, which may differ by geography. Any publication reflects the state of knowledge at the time it was published. The information is not medical advice and cannot replace the independent medical judgement of a healthcare professional.

Journal articles

Increased duration of time without transfusion reliance with imetelstat vs placebo in the phase 3 IMerge trial

Blood Neoplasia

April 16, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Association between treatment-emergent cytopenias and clinical responses to imetelstat in lower-risk myelodysplastic syndromes

Blood Cancer Journal

April 7, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Imetelstat improves patient-reported outcomes and quality of life in lower-risk myelodysplastic syndromes: results from the phase III IMerge study

Haematologica Early View

January 22, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Modulation of the clonal burden in patients with lower-risk myelodysplastic neoplasms treated with imetelstat

Nature Leukemia

January 12, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS

Blood Cancer Journal

December 31, 2025
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower-Risk Myelodysplastic Syndromes

Clinical and Translational Science

December 14, 2025
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling

Frontiers in Oncology

October 1, 2023
Preclinical Data

Imetelstat in patients with lower-risk MDS who have relapsed or are refractory to erythropoiesis-stimulating agents in IMerge phase 3 trial

Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge):…

The Lancet

July 1, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia

Nature Cancer

July 1, 2023
Acute Myeloid Leukemia (AML)Preclinical Data

Telomerase-targeted therapies in myeloid malignancies

Blood Advances

July 1, 2023
Review

Pharmacological Inhibitory Effect of Imetelstat, A Novel Human Telomerase Inhibitor in Diffuse Large B-cell Lymphoma and Peripheral T-Cell Lymphoma

Blood

July 1, 2022
Preclinical Data

Imetelstat in intermediate-2 or high-risk myelofibrosis refractory to JAK inhibitor: IMpactMF phase III study design

Future Oncology

July 1, 2022
Myelofibrosis (MF)Clinical Data

Conference presentations

Real-world Outcomes of Imetelstat: Interrogating Safety, Efficacy and Predictors of Response in Heavily Pretreated Lower-Risk MDS Patients

EHA 2026

June 12, 2026
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Updated analysis of overall survival with imetelstat in relapsed/refractory myelofibrosis versus real-world data, and assessment of real-world treatment patterns

ASCO 2026

June 1, 2026
Myelofibrosis (MF)Clinical Data

Updated protocol: IMproveMF, a Phase 1b trial of imetelstat+ruxolitinib in patients with intermediate-1/2 or high-risk myelofibrosis

ASCO 2026

June 1, 2026
Myelofibrosis (MF)Clinical Data

Correlation between Treatment-Emergent Cytopenias and Clinical Response with Imetelstat (IME) in Patients (Pts) with Lower-Risk Myelodysplastic Syndromes (LR-MDS): Analysis from the IMerge Trial

ASH 2025

December 8, 2025
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Novel Nonlinear Population Pharmacokinetic Model of Imetelstat, a First-in-Class Oligonucleotide Telomerase Inhibitor

ASCPT 2024

March 22, 2024
Clinical Data

Clinical Pharmacology of Imetelstat, a First-in-Class Oligonucleotide Telomerase Inhibitor

ASCPT 2024

March 22, 2024
Clinical Data

Patient-Reported Outcomes Among Heavily Pretreated Patients With Lower-Risk Myelodysplastic Syndromes and High Transfusion Burden Treated With Imetelstat in IMerge

Winter Heme 2024

February 2, 2024
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Efficacy of Imetelstat in Achieving Red Blood Cell Transfusion Independence Across Different Risk Subgroups in Patients With Lower-Risk Myelodysplastic Syndromes Relapsed/Refractory to Erythropoiesis-Stimulating Agents in IMerge Phase 3 Study

ASH 2023

December 5, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Durable Transfusion Independence in Lower-Risk Myelodysplastic Syndrome (LR-MDS) Is Associated With Better Survival: A Population Level Analysis Based on a Large US Health Insurance Claims Database

ASH 2023

December 5, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Impact of Mutational Status on Clinical Response to Imetelstat in Patients With Lower-Risk Myelodysplastic Syndromes in the IMerge Phase 3 Study

ASH 2023

December 5, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Durable Continuous Transfusion Independence (TI) With Imetelstat in IMerge Phase 3 for Patients With Heavily Transfused Non-Del(5q) Lower-Risk Myelodysplastic Syndromes (LR-MDS) Relapsed/Refractory (R/R) to or Ineligible for Erythropoiesis-Stimulating Agents

ASH 2023

December 5, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data

Improvement of Patient-Reported Fatigue in IMerge Phase 3 Trial of Imetelstat versus Placebo in Heavily Transfused Non-Del(5q) Lower-Risk Myelodysplastic Syndromes Relapsed/Refractory/Ineligible to Erythropoiesis Stimulating Agents

AMCP Nexus 2023

October 17, 2023
Lower-risk Myelodysplastic Syndromes (LR-MDS)Clinical Data